Ann Surg Oncol. View abstract. van der Merwe, C. F. Booyens J. Common side effects include a variety of stomach ailments like diarrhea, nausea, abdominal pain, heartburn and a feeling of fullness. side effects of evening primrose oil . Evening primrose oil pills and other supplements containing this ingredient carry potential side effects, from increased bleeding to pregnancy complications. Immunomodulatory and therapeutic effects of Hot-natured diet and co-supplemented hemp seed, evening primrose oils intervention in multiple sclerosis patients. Med Cutan.Ibero.Lat.Am 1986;14(2):133-137. It is mandatory to procure user consent prior to running these cookies on your website. Lovell CR, Burton JL, and Horrobin DF. View abstract. Thuluvath PJ, Triger DR Manku MS Morse-Fisher N. Evening primrose oil in the treatment of severe refractory biliary pruritus. Kwon HS, Lee JH, Kim GM, Choi EH, Bae JM. View abstract. The most common evening primrose side effects are headaches, nausea, indigestion, and soft stools. Randomized trial comparing centchroman to evening primrose oil (letter). Strong A and Hamill E. The effect of combined fish oil and evening primrose oil (Efamol Marine) on the remission phase of psoriasis: a 7-month double-blind randomized placebo-controlled trial. View abstract. All rights reserved. The effect of oral evening primrose oil on bishop score and cervical length amongst term gravidas. 1990;1(4):199-201. Z.Hautkr. Lancet 1985;2:373-7. Jamal GA and Carmichael H. The effects of gamma-linolenic acid on human diabetic peripheral neuropathy: a double-blind placebo-controlled trial. J Nutr Med 1991;2:259-264. Zhongguo Zhong Xi Yi Jie He Za Zhi 1993;13(12):714-7, 707. Evening Primrose Oil is well tolerated and safe if used as recommended. Like most supplements, there hasn't been much research assessing the long-term safety of evening primrose oil. View abstract. Nasri K, Akrami S, Rahimim M, et al. There are certain medical conditions for which evening primrose oil may pose serious health risks. View abstract. Evening primrose plants have been used by humans for a very long time. Does supplementation of formula with evening primrose and fish oils augment long chain polyunsaturated fatty acid status of low birthweight infants to that of breast-fed counterparts? Skin Pharmacol Appl.Skin Physiol 2002;15(1):20-25. Gamma linolenic acid with tamoxifen as primary therapy in breast cancer. The use of Evening Primrose Oil is beneficial in the management of eczema. View abstract. Clinical Uses of Essential Fatty Acids. When taken by mouth, it can sometimes cause mild side effects including upset stomach, nausea, diarrhea, and headache. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Horrobin, D. F. The membrane phospholipid hypothesis as a biochemical basis for the neurodevelopmental concept of schizophrenia. This survey is being conducted by the WebMD marketing sciences department. Rheum.Dis Clin North Am 2000;26(1):13-27, vii. Woltil, H. A., van Beusekom, C. M., Schaafsma, A., Okken, A., and Muskiet, F. A. Answered by Dr. Ed Friedlander: Lots of unknowns: Evening primrose is peddled as … Brush MG. Efamol (evening primrose oil) in the treatment of the premenstrual syndrome. Schizophr.Res 4-10-1998;30(3):193-208. Women Health 1992;19:117-31. Ann Rheum.Dis 1989;48(11):965-966. 2017 Oct 4;6:85. HeadacheDon't take evening primrose if you have a bleeding disorder. Horrobin DF. Attention deficit-hyperactivity disorder (ADHD). View abstract. Liu, H. and Zhou, J. F. [Xianbai buyang Huanwu decoction used for treating hypertension with kidney qi deficiency and blood stasis]. View abstract. II. View abstract. Reduction of 5-azacitidine induced skin reactions in MDS patients with evening primrose oil. 8-12-1995;137(7):169-170. View abstract. Rose DP, Connolly JM, Liu XH. Research evaluating evening primrose for improving childbirth shows conflicting results. J Am Diet Assoc 2000;100:1368-80. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. Evening primrose oil side effects. Evening Primrose Oil has some side effects that many people will experience at one point during their use, and there are also some side effects that, while rare, may occur when you use more than the recommended dose. Lancet 1-31-1981;1(8214):278. Evening primrose oil is probably safe for most adults. J dermatol treat. Meigel, W., Dettke, T., Meigel, E. M., and Lenze, U. Stevinson, C. and Ernst, E. Complementary/alternative therapies for premenstrual syndrome: a systematic review of randomized controlled trials. Out of these cookies, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. (Oxford) 2003;42(5):652-659. Vet.Rec. Jellin JM, Batz F Hitchens K. Pharmacists letter/Prescriber's letter; Natural Comprehensive Database. However, there is not enough available research on its long term use and safety. We also use third-party cookies that help us analyze and understand how you use this website. Khorshidi M, Zarezadeh M, Moradi Moghaddam O, et al. View abstract. You can find GLA in other oils, such as evening primrose and black currant. All information will be used in a manner consistent with the WebMD, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Coronavirus in Context: Interviews With Experts, Sign Up to Receive Our Free Coroanvirus Newsletter, Attention deficit-hyperactivity disorder (ADHD). Yakoot M, Salem A, and Omar AM. Chasteberry Tree? Evening primrose is LIKELY SAFE for most people when used in doses up to 6 grams daily for up to a year. Research evaluating evening primrose for PMS shows conflicting results. However, you may take this herb as per the instructions of a qualified herbal practitioner. Biol Psychiatry 1989;25:222-8. Meta-analysis of placebo-controlled studies of the efficacy of Epogam in the treatment of atopic eczema. Early research shows that taking 2 grams of evening primrose twice daily for 12 weeks improves itchy skin in some people with disorders affecting bile flow in the liver. Liu, L. Z. Wu Q. Liu P. J. Li G. Q. Bensoussan A. Kiat H. Chinese herbal medicines for hypertriglyceridemia. GLA is the part of evening primrose oil that might slow blood clotting. View abstract. View abstract. Dove D, Johnson P. Oral evening primrose oil: its effect on length of pregnancy and selected intrapartum outcomes in low-risk nulliparous women (abstract). View abstract. Br J Surg. Aman MG, Mitchell EA, Turbott SH. Omega-6 essential fatty acids: pathophysiology and roles in clinical medicine. J Nutr 2003;133(11 Suppl 1):3785S-3793S. Evening primrose oil and premenstrual syndrome. Down the primrose path: petechiae in a neonate exposed to herbal remedy for parturition. 2011;32(1):42-51. Lancet 1-28-1995;345(8944):260-261. Laivuori H, Hovatta O, Viinikka L, et al. Yoon, S., Lee, J., and Lee, S. The therapeutic effect of evening primrose oil in atopic dermatitis patients with dry scaly skin lesions is associated with the normalization of serum gamma-interferon levels. Belch J, Hill A. 2003;188(5 Suppl):S56-S65. Larsson B, Jonasson A, and Fianu S. Evening primrose oil in the treatment of premenstrual syndrome. Effect of exercise on FA profiles in n-3 FA-supplemented and -nonsupplemented premenopausal women. This plant belongs to the genus Oenothera, which consists of around 125 species that are commonly known as evening primrose, sun cups or sundrops. View abstract. Evidence-based treatment in family practice. View abstract. View abstract. 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